5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics

Table 5

Mathematical models and parameters based on release data.

	Zero-order	First-order	Higuchi’s	Hixson-Crowell’s	Korsmeyer-Peppas’s		Kopcha’s
pH	Correlation value (𝑅^2)	Correlation value (𝑅^2)	Correlation value (𝑅^2)	Correlation value (𝑅^2)	Correlation value (𝑅^2)	𝑛	Correlation value (𝑅^2)	𝐴/𝐵
3.0	0.77	0.81	0.93	0.80	0.80	0.28	0.89	36.87
4.0	0.76	0.82	0.93	0.80	0.80	0.30	0.93	37.12
5.0	0.81	0.89	0.96	0.87	0.87	0.34	0.97	43.08
6.0	0.76	0.82	0.93	0.80	0.80	0.30	0.92	36.93
7.4	0.75	0.79	0.92	0.78	0.78	0.31	0.93	36.91