Formulation of LDL Targeted Nanostructured Lipid Carriers Loaded with Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and In Vitro Cytotoxicity

Table 1

Definition and trial levels of factors in Taguchi L8 orthogonal array experiment used in production of NLCs loaded with PTX.

Studied variable	Level 1	Level 2
Oleic acid content (w/w %)	15	30
Surfactant type	Poloxamer188	Tween80
Drug/lipid ratio %	5	10
Surfactant concentration %	1	2
Sonication time (min)	2	4
Homogenization rate (rpm)	800	1300