Research Article

Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats

Figure 10

Sirius red-stained tissue sections from the left lungs of a rat intratracheally instilled with 100 μg of Si NW 3 (a) and (b) and 91 (c) days after-exposure. 3 days after-exposure granulomatous-type lesions consisting of macrophages containing Si NW are readily observed (green arrows). By day 91 the alveoli are relatively clear, and the Si NW present are located in AMs (green asterisk).
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(a)
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(b)
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(c)