Research Article

Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats

Table 3

Morphometric analysis of Si NW tissue distribution in rats treated with 100 μg of Si NW.

Lung regionTime after-instillation
Day 1Day 3Day 7Day 28Day 91

Alveolar macrophage (AM) 7 2 . 3 7 ± 3 . 6 1 8 6 . 4 6 ± 5 . 2 1 9 0 . 6 3 ± 5 . 9 8 1 0 0 ± 0 . 0 0 1 0 0 ± 0 . 0 0
Alveolar tissue (AT) 1 8 . 1 5 ± 3 . 2 7 1 1 . 4 6 ± 3 . 9 4 9 . 3 8 ± 5 . 9 8 0 . 0 0 ± 0 . 0 0 0 . 0 0 ± 0 . 0 0
Alveolar airspace (AA) 9 . 4 7 ± 3 . 2 2 2 . 0 8 ± 2 . 0 8 0 . 0 0 ± 0 . 0 0 0 . 0 0 ± 0 . 0 0 0 . 0 0 ± 0 . 0 0