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Journal of Nanomaterials
Volume 2012, Article ID 452767, 11 pages
http://dx.doi.org/10.1155/2012/452767
Research Article

Evaluation on Cartilage Morphology after Intra-Articular Injection of Titanium Dioxide Nanoparticles in Rats

1Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
2Department of Orthopedics, Peking Union Medical College Hospital, Beijing 100730, China

Received 16 November 2011; Accepted 5 January 2012

Academic Editor: Xiaoming Li

Copyright © 2012 Jiangxue Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Park, S. Bauer, K. von der Mark, and P. Schmuki, “Nanosize and vitality: TiO2 nanotube diameter directs cell fate,” Nano Letters, vol. 7, no. 6, pp. 1686–1691, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. X. Li, C. A. van Blitterswijk, Q. Feng, F. Cui, and F. Watari, “The effect of calcium phosphate microstructure on bone-related cells in vitro,” Biomaterials, vol. 29, no. 23, pp. 3306–3316, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. R. N. Shah, N. A. Shah, M. M. D. R. Lim, C. Hsieh, G. Nuber, and S. I. Stupp, “Supramolecular design of self-assembling nanofibers for cartilage regeneration,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 8, pp. 3293–3298, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Engel, A. Michiardi, M. Navarro, D. Lacroix, and J. A. Planell, “Nanotechnology in regenerative medicine: the materials side,” Trends in Biotechnology, vol. 26, no. 1, pp. 39–47, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. X. Li, Q. Feng, X. Liu, W. Dong, and F. Cui, “Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model,” Biomaterials, vol. 27, no. 9, pp. 1917–1923, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. B. D. Boyan, T. W. Hummert, D. D. Dean, and Z. Schwartz, “Role of material surfaces in regulating bone and cartilage cell response,” Biomaterials, vol. 17, no. 2, pp. 137–146, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Burns, C. Yao, and T. J. Webster, “Increased chondrocyte adhesion on nanotubular anodized titanium,” Journal of Biomedical Materials Research—Part A, vol. 88, no. 3, pp. 561–568, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Li, Y. Fan, and F. Watari, “Current investigations into carbon nanotubes for biomedical application,” Biomedical Materials, vol. 5, no. 2, Article ID 022001, 2010. View at Publisher · View at Google Scholar
  9. X. Li, H. Gao, M. Uo et al., “Effect of carbon nanotubes on cellular functions in vitro,” Journal of Biomedical Materials Research—Part A, vol. 91, no. 1, pp. 132–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Li, H. Gao, M. Uo et al., “Maturation of osteoblast-like SaoS2 induced by carbon nanotubes,” Biomedical Materials, vol. 4, no. 1, Article ID 015005, 2009. View at Publisher · View at Google Scholar
  11. G. Giavaresi, L. Ambrosio, G. A. Battiston et al., “Histomorphometric, ultrastructural and microhardness evaluation of the osseointegration of a nanostructured titanium oxide coating by metal-organic chemical vapour deposition: an in vivo study,” Biomaterials, vol. 25, no. 25, pp. 5583–5591, 2004. View at Publisher · View at Google Scholar
  12. A. Hatton, J. E. Nevelos, J. B. Matthews, J. Fisher, and E. Ingham, “Effects of clinically relevant alumina ceramic wear particles on TNF-α production by human peripheral blood mononuclear phagocytes,” Biomaterials, vol. 24, no. 7, pp. 1193–1204, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Niimi, M. Hasegawa, A. Sudo, and A. Uchida, “A large metallic cyst caused by wear particles after total knee arthroplasty,” Archives of Orthopaedic and Trauma Surgery, vol. 127, no. 1, pp. 51–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. S. Kuster, P. Podsiadlo, and G. W. Stachowiak, “Shape of wear particles found in human knee joints and their relationship to osteoarthritis,” British Journal of Rheumatology, vol. 37, no. 9, pp. 978–984, 1998. View at Google Scholar · View at Scopus
  15. M. Lapcikova, M. Slouf, J. Dybal et al., “Nanometer size wear debris generated from ultra high molecular weight polyethylene in vivo,” Wear, vol. 266, no. 1-2, pp. 349–355, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Milošev and M. Remškar, “In vivo production of nanosized metal wear debris formed by tribochemical reaction as confirmed by high-resolution TEM and XPS analyses,” Journal of Biomedical Materials Research—Part A, vol. 91, no. 4, pp. 1100–1110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Nel, T. Xia, L. Mädler, and N. Li, “Toxic potential of materials at the nanolevel,” Science, vol. 311, no. 5761, pp. 622–627, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. D. B. Warheit, R. A. Hoke, C. Finlay, E. M. Donner, K. L. Reed, and C. M. Sayes, “Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management,” Toxicology Letters, vol. 171, no. 3, pp. 99–110, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Stone and K. Donaldson, “Nanotoxicology: signs of stress,” Nature Nanotechnology, vol. 1, no. 1, pp. 23–24, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Wang, Y. Liu, F. Jiao et al., “Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles,” Toxicology, vol. 254, no. 1-2, pp. 82–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. X. Lu, L. Zhou, Z. L. Zhang et al., “Cell damage induced by photocatalysis of TiO2 thin films,” Langmuir, vol. 19, no. 21, pp. 8765–8768, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. W. G. Wamer, J. J. Yin, and R. R. Wei, “Oxidative damage to nucleic acids photosensitized by titanium dioxide,” Free Radical Biology and Medicine, vol. 23, no. 6, pp. 851–858, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Hussain, S. Boland, A. Baeza-Squiban et al., “Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles: role of particle surface area and internalized amount,” Toxicology, vol. 260, no. 1–3, pp. 142–149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. J. X. Wang, Y. B. Fan, Y. Gao, Q. H. Hu, and T. C. Wang, “TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection,” Biomaterials, vol. 30, no. 27, pp. 4590–4600, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. S. R. Goldring, “Pathogenesis of bone and cartilage destruction in rheumatoid arthritis,” Rheumatology, vol. 42, no. 2, pp. ii11–ii16, 2003. View at Google Scholar · View at Scopus
  26. F. Rannou, M. François, M. T. Corvol, and F. Berenbaum, “Cartilage breakdown in rheumatoid arthritis,” Joint Bone Spine, vol. 73, no. 1, pp. 29–36, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. D. E. T. Shepherd and B. B. Seedhom, “Thickness of human articular cartilage in joints of the lower limb,” Annals of the Rheumatic Diseases, vol. 58, no. 1, pp. 27–34, 1999. View at Google Scholar · View at Scopus
  28. J. S. Jurvelin, T. Räsänen, P. Kolmonens, and T. Lyyra, “Comparison of optical, needle probe and ultrasonic techniques for the measurement of articular cartilage thickness,” Journal of Biomechanics, vol. 28, no. 2, pp. 231–235, 1995. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Eckstein, H. Sittek, S. Milz et al., “The potential of magnetic resonance imaging (MRI) for quantifying articular cartilage thickness—a methodological study,” Clinical Biomechanics, vol. 10, no. 8, pp. 434–440, 1995. View at Publisher · View at Google Scholar · View at Scopus
  30. R. E. Golding, W. F. Ponder, and M. Byrne, “Three-dimensional reconstruction of the odontophoral cartilages of caenogastropoda (mollusca: gastropoda) using micro-ct: morphology and phylogenetic significance,” Journal of Morphology, vol. 270, no. 5, pp. 558–587, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Almajdub, L. Magnier, L. Juillard, and M. Janier, “Kidney volume quantification using contrast-enhanced in vivo X-ray micro-CT in mice,” Contrast Media and Molecular Imaging, vol. 3, no. 3, pp. 120–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Almajdub, M. Nejjari, G. Poncet et al., “In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice,” Contrast Media and Molecular Imaging, vol. 2, no. 2, pp. 88–93, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. A. W. Palmer, R. E. Guldberg, and M. E. Levenston, “Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 51, pp. 19255–19260, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Xie, A. S. P. Lin, M. E. Levenston, and R. E. Guldberg, “Quantitative assessment of articular cartilage morphology via EPIC-μCT,” Osteoarthritis and Cartilage, vol. 17, no. 3, pp. 313–320, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. H. J. Agins, N. W. Alcock, M. Bansal et al., “Metallic wear in failed titanium-alloy total hip replacements. A histological and quantitative analysis,” Journal of Bone and Joint Surgery—Series A, vol. 70, no. 3, pp. 347–356, 1988. View at Google Scholar · View at Scopus
  36. R. L. Karvonen, W. G. Negendank, R. A. Teitge, A. H. Reed, P. R. Miller, and F. Fernandez- Madrid, “Factors affecting articular cartilage thickness in osteoarthritis and aging,” Journal of Rheumatology, vol. 21, no. 7, pp. 1310–1318, 1994. View at Google Scholar · View at Scopus
  37. W. H. van der Laan, P. H. A. Quax, C. A. Seemayer et al., “Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3,” Gene Therapy, vol. 10, no. 3, pp. 234–242, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Seckinger, I. Yaron, F. A. Meyer, M. Yaron, and J. M. Dayer, “Modulation of the effects of interleukin-1 on glycosaminoglycan synthesis by the urine-derived interleukin-1 inhibitor, but not by interleukin-6,” Arthritis and Rheumatism, vol. 33, no. 12, pp. 1807–1814, 1990. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Meachim, G. Bentley, and R. Baker, “Effect of age on thickness of adult patellar articular cartilage,” Annals of the Rheumatic Diseases, vol. 36, no. 6, pp. 563–568, 1977. View at Google Scholar · View at Scopus
  40. H. Brommer, P. A. J. Brama, M. S. Laasanen, H. J. Helminen, P. R. Van Weeren, and J. S. Jurvelin, “Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis,” Equine Veterinary Journal, vol. 37, no. 2, pp. 148–154, 2005. View at Google Scholar · View at Scopus
  41. N. Mitchell and N. Shepard, “The ultrastructure of articular cartilage in rheumatoid arthritis. A preliminary report,” Journal of Bone and Joint Surgery—Series A, vol. 52, no. 7, pp. 1405–1423, 1970. View at Google Scholar · View at Scopus
  42. H. A. Kim and Y. W. Song, “Apoptotic chondrocyte death in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 42, no. 7, pp. 1528–1537, 1999. View at Publisher · View at Google Scholar · View at Scopus