Preparation of Folate-Conjugated Pluronic F127/Chitosan Core-Shell Nanoparticles Encapsulating Doxorubicin for Breast Cancer Treatment

Figure 6

Fluorescence images of cellular distribution of free DOX ((a) 1 hour, (b) 2 hour, and (c) 24 hour incubation) and DOX-loaded folate-conjugated chitosan core-shell nanoparticles ((d) 1 hour, (e) 2 hour, and (f) 24 hour incubation) in MCF-7 cells. The arrows indicate the accumulation of DOX at the cell nuclei. Magnifications: 20X.