Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs

Table 2

Targeted micelle formulations.

Ligand type	Ligand	Target	Copolymer	Reference
Antibody	mAb 2C5	Nucleosome-restricted specificity for different cancer cells	PEG-b-PE	[54]
	mAb C225	EGF receptor	PEG-b-PG	[55]
	mAb HD39-SA	CD22	Biotinylated PDMAEMA-b-DMAEMA-BMA-PAA	[56]
Peptide	ligand (cRGDfK)	integrin	PEG-b-PCL	[57]
	VPAC2	Vasoactive intestinal peptide receptor	DSPE-PEG3400-NHS	[58]
	Angiopep-2	Lipoprotein receptor-related protein (LRP) present on the BBB	PE-PEG	[59]
	WYRGRL	Collagen II α1	Pluronic F-127	[31]
Others	Folate	Folate receptor	PLGA-b-PEG	[60]
			mPEG-b-PCL	[61]
			PEG3350-DSPE: mPEG2300-DSPE(1 : 100)	[62]
	Galactosamine	Asialoglycoprotein receptor (ASGP-R)	PCL67-PEEP36-CDI	[63]