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Journal of Nanomaterials
Volume 2012, Article ID 731592, 7 pages
Research Article

Biocompatibility of Nanoporous TiO2 Coating on NiTi Alloy Prepared via Dealloying Method

1Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
2Center of Material Physics and Chemistry, Beihang University, Beijing 100191, China
3Orthopedic Institute and The Second Hospital of Lanzhou University, Lanzhou 730030, China
4Research Division, Gansu Seemine Material High-Tech Co. Ltd., Lanzhou 730030, China

Received 2 March 2012; Accepted 30 March 2012

Academic Editor: Xiaoming Li

Copyright © 2012 Jin Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper investigated the biocompatibility of nanoporous TiO2 coating on NiTi shape-memory alloy (SMA) prepared via dealloying method. Our previous study shows that the dealloying treatment at low temperature leads to 130 nm Ni-free surface titania surface layer, which possesses good bioactivity because of the combination of hydroxyl (OH) group in the process of dealloying treatment simultaneously. In this paper, the biological compatibility of NiTi alloy before and after dealloying treatment was evaluated and compared by direct contact method with dermal mesenchymal stem cells (DMSCs) by the isolated culture way. The interrelation between the biological compatibility and surface change of material after modification was systematically analyzed. As a consequence, the dealloying treatment method at low temperature could be of interest for biomedical application, as it can avoid sensitization and allergies and improve biocompatibility of NiTi shape-memory alloys. Thus it laid the foundation of the clinical trials for surface modification of NiTi memory alloy.