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Journal of Nanomaterials
Volume 2012, Article ID 746960, 11 pages
http://dx.doi.org/10.1155/2012/746960
Research Article

Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin

1Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
2Department of Obstetrics and Gynecology, China Medical University and Hospital, 91 Hsueh Shih Road, Taichung 404, Taiwan
3College of Medicine, China Medical University, Taichung 40402, Taiwan
4Institute of Chemical Kinetics & Combustion, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia
5Institute of Electrical Control Engineering, National Chiao Tung University, 1001 University Road, EE772, Hsinchu 300, Taiwan
6Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia

Received 5 April 2012; Accepted 14 May 2012

Academic Editor: Xiaoming Li

Copyright © 2012 Yu-Shiun Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Melanin prevented that the injected GNPs might damage hippocampus. Hematoxylin-Eosin staining showed GNP-induced abnormality in hippocampus. Pretreatment of melanin completely alleviated GNP-induced impairment of cognition

  1. Supplementary Figure