Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes
Figure 5
HNT-liposome surfaces simultaneously enhance MCF7 and COLO 205 cell adhesion and reduce neutrophil adhesion from a combined suspension of cancer cells and neutrophils. (a) MCF7 cells (red arrow) and neutrophils (yellow arrow) adhered to a smooth microtube coated with ES-PEG L-DXR. Scale bar = 100 μm. (b) MCF7 cells (red arrow) and neutrophils (yellow arrow) adhered to an HNT-coated microtube with immobilized ES-PEG L-DXR. Scale bar = 100 μm. (c) Number of MCF7 cells adhered to smooth and HNT-coated microtubes per 100,000 μm2. (d) Number of COLO 205 cells adhered to smooth and HNT-coated microtubes per 100,000 μm2. (e) Number of neutrophils adhered to smooth and HNT-coated microtubes per 100,000 μm2. *.
