Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design

Table 3

Particle size, zeta potential, loading efficiency, and release efficiency (RE₂%) of different doxorubicin loaded in folate-targeted DEX/RA micelles (mean ± SD; 𝑛=3).

Formulation code	Particle size (nm)	PDI index	Zeta potential (mv)	Loading efficiency %	RE2%
F1	194.4±12.9	0.2±0.0	−1.1	96.1±0.9	72.6±1.5
F2	83.9±4.6	0.3±0.0	−2.0	82.9±0.6	49.6±2.1
F3	140.2±29.6	0.4±0.2	−3.5	92.3±1.5	68.1±1.5
F4	167.3±6.7	0.3±0.0	−2.4	100.0±0.0	67.0±1.5
F5	128.7±6.7	0.4±0.1	−4.8	100.0±0.0	64.1±0.5
F6	89.1±3.6	0.5±0.0	−5.5	91.5±1.2	75.3±1.0
F7	163.0±31.2	0.5±0.4	−3.9	100.0±0.0	61.0±1.8
F8	113.0±17.2	0.5±0.1	−7.9	100.0±0.0	58.9±2.0