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Journal of Nanomaterials
Volume 2012 (2012), Article ID 930931, 11 pages
http://dx.doi.org/10.1155/2012/930931
Research Article

Assessment of Pulmonary Fibrogenic Potential of Multiwalled Carbon Nanotubes in Human Lung Cells

1Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
2Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA

Received 13 January 2012; Revised 25 March 2012; Accepted 25 March 2012

Academic Editor: Ivo Iavicoli

Copyright © 2012 Anurag Mishra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • Warangkana Lohcharoenkal, Liying Wang, Todd A. Stueckle, Cerasela Zoica Dinu, Vincent Castranova, Yuxin Liu, and Yon Rojanasakul, “Chronic Exposure to Carbon Nanotubes Induces Invasion of Human Mesothelial Cells through Matrix Metalloproteinase-2,” ACS Nano, pp. 130812090524000, 2013. View at Publisher · View at Google Scholar
  • Brandi N. Snyder-Talkington, Julian Dymacek, Dale W. Porter, Michael G. Wolfarth, Robert R. Mercer, Maricica Pacurari, James Denvir, Vincent Castranova, Yong Qian, and Nancy L. Guo, “System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses,” Toxicology and Applied Pharmacology, 2013. View at Publisher · View at Google Scholar
  • Liying Wang, Todd A. Stueckle, Anurag Mishra, Raymond Derk, Terence Meighan, Vincent Castranova, and Yon Rojanasakul, “Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells,” Nanotoxicology, pp. 1–23, 2013. View at Publisher · View at Google Scholar
  • Amruta Manke, Liying Wang, and Yon Rojanasakul, “Pulmonary toxicity and fibrogenic response of carbon nanotubes,” Toxicology Mechanisms and Methods, vol. 23, no. 3, pp. 196–206, 2013. View at Publisher · View at Google Scholar
  • Sudjit Luanpitpong, Liying Wang, Arnruta Manke, Karen H. Martin, Amanda Gatesman Ammer, Vincent Castranova, Yong Yang, and Yon Rojansaku, “Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis,” Nano Letters, vol. 14, no. 6, pp. 3110–3116, 2014. View at Publisher · View at Google Scholar
  • Sudjit Luanpitpong, Liying Wang, and Yon Rojanasakul, “The effects of carbon nanotubes on lung and dermal cellular behaviors,” Nanomedicine, vol. 9, no. 6, pp. 895–912, 2014. View at Publisher · View at Google Scholar
  • Tian Chen, Haiyu Nie, Xin Gao, Jinglin Yang, Ji Pu, Zhangjian Chen, Xiaoxing Cui, Yun Wang, Haifang Wang, and Guang Jia, “Epithelial-Mesenchymal Transition Involved in Pulmonary Fibrosis Induced by Multi-Walled Carbon Nanotubes via TGF-beta/Smad Signaling Pathway,” Toxicology Letters, 2014. View at Publisher · View at Google Scholar
  • Nivedita Chatterjee, JiSu Yang, Hyun-Mi Kim, Eunhye Jo, Phil-Je Kim, Kyunghee Choi, and Jinhee Choi, “ Potential Toxicity of Differential Functionalized Multiwalled Carbon Nanotubes (MWCNT) in Human Cell Line (BEAS2B) and Caenorhabditis elegans ,” Journal of Toxicology and Environmental Health, Part A, vol. 77, no. 22-24, pp. 1399–1408, 2014. View at Publisher · View at Google Scholar
  • Cinzia Lucia Ursini, Raffaele Maiello, Aureliano Ciervo, Anna Maria Fresegna, Giuliana Buresti, Fabiana Superti, Magda Marchetti, Sergio Iavicoli, and Delia Cavallo, “Evaluation of uptake, cytotoxicity and inflammatory effects in respiratory cells exposed to pristine and -OH and -COOH functionalized multi-wall carbon nanotubes,” Journal of Applied Toxicology, 2015. View at Publisher · View at Google Scholar
  • Amy L. Mihalchik, Weiqiang Ding, Dale W. Porter, Colleen McLoughlin, Diane Schwegler-Berry, Jennifer D. Sisler, Aleksandr B. Stefaniak, Brandi N. Snyder-Talkington, Rodolfo Cruz-Silva, Mauricio Terrones, Shuji Tsuruoka, Morinobu Endo, Vincent Castranova, and Yong Qian, “Effects of nitrogen-doped multi-walled carbon nanotubes compared to pristine multi-walled carbon nanotubes on human small airway epithelial cells,” Toxicology, 2015. View at Publisher · View at Google Scholar
  • Anurag Mishra, Todd A. Stueckle, Robert R. Mercer, Raymond Derk, Yon Rojanasakul, Vincent Castranova, and Liying Wang, “Identification of TGF-beta receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis,” American Journal Of Physiology-Lung Cellular And Molecular Physiology, vol. 309, no. 8, pp. L821–L833, 2015. View at Publisher · View at Google Scholar
  • Penny Nymark, Peter Wijshoff, Rachel Cavill, Marcel van Herwijnen, Maarten L. J. Coonen, Sandra Claessen, Julia Catalan, Hannu Norppa, Jos C. S. Kleinjans, and Jacob J. Briede, “Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carb,” Nanotoxicology, vol. 9, no. 5, pp. 624–635, 2015. View at Publisher · View at Google Scholar
  • Amy J. Clippinger, Annie M. Jarabek, William Polk, Barbara Rothen-Rutishauser, Christie M. Sayes, Phil Sayre, Arti Ahluwalia, Warren Casey, Vincent Castranova, Monika Maier, Monita Sharma, Vicki Stone, David Allen, James C. Bonner, Raymond M. David, Sabina Halappanavar, and Jon A. Hotchkiss, “Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials,” Archives of Toxicology, vol. 90, no. 7, pp. 1769–1783, 2016. View at Publisher · View at Google Scholar
  • Monita Sharma, Jake Nikota, Sabina Halappanavar, Vincent Castranova, Barbara Rothen-Rutishauser, and Amy J. Clippinger, “Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs),” Archives of Toxicology, vol. 90, no. 7, pp. 1605–1622, 2016. View at Publisher · View at Google Scholar
  • Manuela Polimeni, Giulia Rossana Gulino, Elena Gazzano, Joanna Kopecka, Arianna Marucco, Ivana Fenoglio, Federico Cesano, Luisa Campagnolo, Andrea Magrini, Antonio Pietroiusti, Dario Ghigo, and Elisabetta Aldieri, “Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-beta-mediated Akt/GSK-,” Particle And Fibre Toxicology, vol. 13, 2016. View at Publisher · View at Google Scholar
  • William W. Polk, Monita Sharma, Christie M. Sayes, Jon A. Hotchkiss, and Amy J. Clippinger, “Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface,” Particle And Fibre Toxicology, vol. 13, 2016. View at Publisher · View at Google Scholar
  • Todd A. Stueckle, Donna C. Davidson, Ray Derk, Peng Wang, Sherri Friend, Diane Schwegler-Berry, Peng Zheng, Nianqiang Wu, Vince Castranova, Yon Rojanasakul, and Liying Wang, “Effect of surface functionalizations of multi-walled carbon nanotubes on neoplastic transformation potential in primary human lung epithelial cells,” Nanotoxicology, pp. 1–12, 2017. View at Publisher · View at Google Scholar