Silver Nanoparticles in Alveolar Bone Surgery Devices

Table 3

Studies about scaffolds containing Ag NPs proposed in alveolar bone regenerative surgery.

Author, year	Type of study	Device	Description of Ag NPs included	Main results
Wu et al., 2010 [13]	In vitro	Antimicrobial composite scaffolds	Ag-nHA/TiO2/PA66	(i) Ag^+ release: time and concentration dependent.
				(ii) Ag^+ release properties influenced by the immersion medium.
Saravanan et al., 2011 [5]	In vitro	Bio-composite scaffold for bone tissue engineering	Chitosan/nano-hydroxyapatite/nano-silver	(i) Antibacterial activity against both Gram-positive and Gram-negative bacteria.
				(ii) Non-toxic to rat osteoprogenitor cells and human osteosarcoma cell line.
Schneider et al., 2011 [15]	In vivo, animal	Cotton wool-like flexible artificial bone substitutes	PLGA/Ag-CaP	(i) Bone formation was not negatively influenced by the 0.4% silver.
				(ii) Area fraction of new bone in formation after 8 weeks implantation in hole defects of long bone in sheep was very similar for PLGA/CaP and PLGA/Ag-CaP.