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Journal of Nanomaterials
Volume 2013 (2013), Article ID 349140, 9 pages
Research Article

Titanium Dioxide Nanoparticles Induced Proinflammation of Primary Cultured Cardiac Myocytes of Rat

1Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
2Research Institute of Beihang University in Shenzhen, Shenzhen 518057, China

Received 14 June 2013; Accepted 26 July 2013

Academic Editor: Xiaoming Li

Copyright © 2013 Wei Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Titanium dioxide (TiO2) nanoparticles are widely used in electronics, biology, and medicine owing to their special properties. However, during TiO2 nanoparticles exposure, nanoparticles may enter the blood circulation and translocate to the heart, and they may result in negative effects on the cardiovascular system. In this study, we demonstrated that the anatase and rutile TiO2 nanoparticles had potential toxicological effects on primary cultured cardiac myocytes of rat. After incubating with the anatase and rutile TiO2 nanoparticles, the primary cultured cardiac myocytes had become elongated and appeared to detach from the surface of cell plate. After exposure to 50, 100, and 150 μg/mL anatase and rutile TiO2 nanoparticles for 2 days, the obvious decrease of cell viability was observed. And further studies showed that TiO2 nanoparticles exposure could induce the high expression of proinflammatory cytokines TNF-α and IL-6, especially in 150 μg/mL group. The long-rod rutile TiO2 had more strong effects on cell viability and proinflammatory cytokines induction than red-blood cells like anatase TiO2. Results indicated that TiO2 nanoparticles exposure could impair the function of primary cultured cardiac myocytes of rat. Therefore, these findings support the view that much more attention should be aroused on the application of these nanoparticles and their potential exposure effects on human beings.