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Journal of Nanomaterials
Volume 2013, Article ID 351810, 12 pages
http://dx.doi.org/10.1155/2013/351810
Research Article

Synthesis and Characterization of Drug-Loaded Poly( -caprolactone)/Silica Hybrid Nanofibrous Scaffolds

1Department of Dental Laboratory Science and Engineering, Korea University, Seoul 136-703, Republic of Korea
2Department of Orthopaedics, Korea University Medical Center, Guro Hospital, Seoul 152-703, Republic of Korea
3Department of Materials Science and Engineering, Seoul National University, Seoul 151-742, Republic of Korea

Received 19 July 2013; Revised 27 September 2013; Accepted 27 September 2013

Academic Editor: Raghavendra Hegde

Copyright © 2013 Kwan-Ha Shin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. M. Stevens and J. H. George, “Exploring and engineering the cell surface interface,” Science, vol. 310, no. 5751, pp. 1135–1138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Gronthos, P. J. Simmons, S. E. Graves, and P. G. Robey, “Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix,” Bone, vol. 28, no. 2, pp. 174–181, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. M. P. Lutolf and J. A. Hubbell, “Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering,” Nature Biotechnology, vol. 23, no. 1, pp. 47–55, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Schindler, I. Ahmed, J. Kamal et al., “A synthetic nanofibrillar matrix promotes in vivo-like organization and morphogenesis for cells in culture,” Biomaterials, vol. 26, no. 28, pp. 5624–5631, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Ishii, T. H. Ying, A. Mahara et al., “In vivo tissue response and degradation behavior of PLLA and stereocomplexed PLA nanofibers,” Biomacromolecules, vol. 10, no. 2, pp. 237–242, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Teo, W. He, and S. Ramakrishna, “Electrospun scaffold tailored for tissue-specific extracellular matrix,” Biotechnology Journal, vol. 1, no. 9, pp. 918–929, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Agarwal, J. H. Wendorff, and A. Greiner, “Progress in the field of electrospinning for tissue engineering applications,” Advanced Materials, vol. 21, no. 32-33, pp. 3343–3351, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. J. H. Jang, O. Castano, and H. W. Kim, “Electrospun materials as potential platforms for bone tissue engineering,” Advanced Drug Delivery Reviews, vol. 61, no. 12, pp. 1065–1083, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. E. R. Kenawy, G. L. Bowlin, K. Mansfield et al., “Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend,” Journal of Controlled Release, vol. 81, no. 1-2, pp. 57–64, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Taepaiboon, U. Rungsardthong, and P. Supaphol, “Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs,” Nanotechnology, vol. 17, no. 9, pp. 2317–2329, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Kanawung, K. Panitchanapan, S. Puangmalee et al., “Preparation and characterization of polycaprolactone/ diclofenac sodium and poly(vinyl alcohol)/tetracycline hydrochloride fiber mats and their release of the model drugs,” Polymer Journal, vol. 39, no. 4, pp. 369–378, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. X. Meng, W. Zheng, L. Li, and Y. F. Zheng, “Fabrication, characterization and in vitro drug release behavior of electrospun PLGA/chitosan nanofibrous scaffold,” Materials Chemistry and Physics, vol. 125, no. 3, pp. 606–611, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Zahedi, Z. Karami, I. Rezaeian et al., “Preparation and performance evaluation of tetracycline hydrochloride loaded wound dressing mats based on electrospun nanofibrous poly(lactic acid)/poly(εμ-caprolactone) blends,” Journal of Applied Polymer Science, vol. 124, no. 5, pp. 4174–4183, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. L. A. Mary, T. Senthilram, S. Suganya et al., “Centrifugal spun ultrafine fibrous web as a potential drug delivery vehicle,” Express Polymer Letters, vol. 7, pp. 238–248, 2013. View at Publisher · View at Google Scholar
  15. A. M. Le Ray, S. Chiffoleau, P. Iooss et al., “Vancomycin encapsulation in biodegradable poly(ε-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility,” Biomaterials, vol. 24, no. 3, pp. 443–449, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Meseguer-Olmo, M. J. Ros-Nicolás, M. Clavel-Sainz et al., “Biocompatibility and in vivo gentamicin release from bioactive sol-gel glass implants,” Journal of Biomedical Materials Research, vol. 61, no. 3, pp. 458–465, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. W. J. Li, K. G. Danielson, P. G. Alexander, and R. S. Tuan, “Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(ε-caprolactone) scaffolds,” Journal of Biomedical Materials Research A, vol. 67, no. 4, pp. 1105–1114, 2003. View at Google Scholar · View at Scopus
  18. H. Yoshimoto, Y. M. Shin, H. Terai, and J. P. Vacanti, “A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering,” Biomaterials, vol. 24, no. 12, pp. 2077–2082, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Shin, H. Yoshimoto, and J. P. Vacanti, “In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold,” Tissue Engineering, vol. 10, no. 1-2, pp. 33–41, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. M. S. Khil, S. R. Bhattarai, H. Y. Kim, S. Kim, and K. Lee, “Novel fabricated matrix via electrospinning for tissue engineering,” Journal of Biomedical Materials Research B, vol. 72, no. 1, pp. 117–124, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Fujihara, M. Kotaki, and S. Ramakrishna, “Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers,” Biomaterials, vol. 26, no. 19, pp. 4139–4147, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Wutticharoenmongkol, N. Sanchavanakit, P. Pavasant, and P. Supaphol, “Novel bone scaffolds of electrospun polycaprolactone fibers filled with nanoparticles,” Journal of Nanoscience and Nanotechnology, vol. 6, no. 2, pp. 514–522, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Erisken, D. M. Kalyon, and H. Wang, “Functionally graded electrospun polycaprolactone and β-tricalcium phosphate nanocomposites for tissue engineering applications,” Biomaterials, vol. 29, no. 30, pp. 4065–4073, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. E. M. Valliant and J. R. Jones, “Softening bioactive glass for bone regeneration: sol-gel hybrid materials,” Soft Matter, vol. 7, no. 11, pp. 5083–5095, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. E. J. Lee, S. H. Teng, T. S. Jang et al., “Nanostructured poly(ε-caprolactone)-silica xerogel fibrous membrane for guided bone regeneration,” Acta Biomaterialia, vol. 6, no. 9, pp. 3557–3565, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. T. S. Jang, E. J. Lee, J. H. Jo et al., “Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration,” Journal of Biomedical Materials Research B, vol. 100, no. 2, pp. 321–330, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Lei, K. H. Shin, D. Y. Noh et al., “Nanofibrous gelatin-silica hybrid scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation,” Journal of Materials Chemistry, vol. 22, pp. 14133–14140, 2012. View at Publisher · View at Google Scholar
  28. Y. Wu, C. Wu, Y. Li, T. Xu, and Y. Fu, “PVA-silica anion-exchange hybrid membranes prepared through a copolymer crosslinking agent,” Journal of Membrane Science, vol. 350, no. 1-2, pp. 322–332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Cheng, D. Shen, X. Zhu, X. Tian, D. Zhou, and L. Fan, “Preparation of nonwoven polyimide/silica hybrid nanofiberous fabrics by combining electrospinning and controlled in situ sol-gel techniques,” European Polymer Journal, vol. 45, no. 10, pp. 2767–2778, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Cao, Y. P. Wu, Z. F. Fu et al., “Cell adhesive and growth behavior on electrospun nanofibrous scaffolds by designed multifunctional composites,” Colloids and Surfaces B, vol. 84, no. 1, pp. 26–34, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. R. R. Duling, R. B. Dupaix, N. Katsube, and J. Lannutti, “Mechanical characterization of electrospun polycaprolactone (PCL): a potential scaffold for tissue engineering,” Journal of Biomechanical Engineering, vol. 130, no. 1, Article ID 011006, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. V. Pillay, C. Dott, Y. E. Choonara et al., “A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications,” Journal of Nanomaterials, vol. 2013, Article ID 789289, 22 pages, 2013. View at Publisher · View at Google Scholar
  33. A. Mohamed, V. L. Finkenstadt, S. H. Gordon, G. Biresaw, E. Palmquist Debra, and P. Rayas-Duarte, “Thermal properties of PCL/gluten bioblends characterized by TGA, DSC, SEM, and infrared-PAS,” Journal of Applied Polymer Science, vol. 110, no. 5, pp. 3256–3266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Sayyar, E. Murray, B. C. Thompson, S. Gambhir, D. L. Officer, and G. G. Wallace, “Covalently linked biocompatible graphene/polycaprolactone composites for tissue engineering,” Carbon, vol. 52, pp. 296–304, 2013. View at Publisher · View at Google Scholar
  35. J. L. E. Ivirico, M. S. Sánchez, R. Sabater i Serra, J. M. M. Dueñas, J. L. G. Ribelles, and M. M. Pradas, “Structure and properties of poly(ε-caprolactone) networks with modulated water uptake,” Macromolecular Chemistry and Physics, vol. 207, no. 23, pp. 2195–2205, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. D. Verma, K. Katti, and D. Katti, “Bioactivity in in situ hydroxyapatite-polycaprolactone composites,” Journal of Biomedical Materials Research A, vol. 78, no. 4, pp. 772–780, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. S. H. Jun, E. J. Lee, S. W. Yook, H. E. Kim, H. W. Kim, and Y. H. Koh, “A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process,” Acta Biomaterialia, vol. 6, no. 1, pp. 302–307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Fidalgo and L. M. Ilharco, “The influence of the wet gels processing on the structure and properties of silica xerogels,” Microporous and Mesoporous Materials, vol. 84, no. 1–3, pp. 229–235, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. E. J. Lee, S. H. Teng, T. S. Jang et al., “Nanostructured poly(ε-caprolactone)-silica xerogel fibrous membrane for guided bone regeneration,” Acta Biomaterialia, vol. 6, no. 9, pp. 3557–3565, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. L. F. Zhang, R. Sun, L. Xu et al., “Hydrophilic poly (ethylene glycol) coating on PDLLA/BCP bone scaffold for drug delivery and cell culture,” Materials Science and Engineering C, vol. 28, no. 1, pp. 141–149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. J. P. St-Pierre, M. Gauthier, L. P. Lefebvre, and M. Tabrizian, “Three-dimensional growth of differentiating MC3T3-E1 pre-osteoblasts on porous titanium scaffolds,” Biomaterials, vol. 26, no. 35, pp. 7319–7328, 2005. View at Publisher · View at Google Scholar · View at Scopus