Obtaining of Sol-Gel Ketorolac-Silica Nanoparticles: Characterization and Drug Release Kinetics

Table 2

Linearization coefficients obtained from in vitro release of Ketorolac from SiO₂.

Reservoir	Zero-order	First-order	Higuchi	Hixon-crowel	Hyperbola
	𝑄𝑡=𝑄0+𝐾0𝑡	𝑄𝑡=ln𝑄0−𝐾1𝑡	𝑄𝑡=𝑘𝐻𝑡^1/2	𝑊0^1/3 −𝑊𝑡^1/3=𝐾𝑠𝑡	𝑎∗𝑥/(𝑏+𝑥)
Ketorolac SiO2 1 : 8	0.4183	0.6809	0.5980	0.5712	0.9651
Ketorolac SiO2 1 : 4	0.7496	0.9664	0.8644	0.8919	0.9516

𝑄_𝑡: amount of drug released in time t.
𝑄₀: initial amount of drug in the tablet.
𝐾₀, 𝐾₁, 𝑘_𝐻, 𝐾_𝑠: release rate constants.
b: shape parameter.
a: scale parameter.