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Journal of Nanomaterials
Volume 2013, Article ID 623497, 6 pages
http://dx.doi.org/10.1155/2013/623497
Research Article

Evaluation of the Antitumor Activity by Ni Nanoparticles with Verbascoside

1Department of Biomedical Engineering, School of Kangda, Nanjing Medical University, Nanjing 210029, China
2Department of Biochemical Molecular, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China
3Department of Radiology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210009, China
4Institute of Stomatology, Nanjing Medical University, Nanjing 210029, China
5Department of Biomedical Engineering, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China
6Department of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China

Received 1 September 2013; Revised 25 October 2013; Accepted 4 November 2013

Academic Editor: Mengnan Qu

Copyright © 2013 Mingyue Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Verbascoside (VB) has attracted a great deal of attention due to ITS pharmacological properties. In our study, we synthesized a multifunctional verbascoside coated Ni nanoparticles (VB-Ni). Transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC) display the characteristics of VB-Ni nanoparticles. Compared with VB, VB-Ni has been proven to induce apoptosis and resist the growth of doxorubicin-resistant K562 cells in vitro and in vivo. Thus, VB-Ni nanoparticles can be thought of as an ideal mode of cancer treatment.