Physicochemical Properties and In Vitro Cytotoxicity Studies of Chitosan as a Potential Carrier for Dicer-Substrate siRNA

Table 1

Particle size, PDI, and zeta potential of DsiRNA-CS NPs/complexes, 𝑛=3.

CS concentration (% 𝑤/𝑣)	Simple complexation			Adsorption
	Particle size (nm) ± SD	PDI ± SD	Zeta potential (mV) ± SD	Particle size (nm) ± SD	PDI ± SD	Zeta potential; (mV) ± SD
0.1	270.33 ± 56.14	0.60 ± 0.06	+56.77 ± 7.64	216.37 ± 45.52	0.59 ± 0.06	+40.50 ± 2.95
0.2	404.13 ± 10.64	0.75 ± 0.17	+57.10 ± 6.22	231.00 ± 68.78	0.52 ± 0.18	+46.13 ± 4.21
0.3	624.67 ± 64.90	0.69 ± 0.08	+68.50 ± 1.87	251.23 ± 33.80	0.53 ± 0.10	+37.27 ± 6.07
0.4	734.40 ± 73.73	0.72 ± 0.19	+69.23 ± 5.05	336.50 ± 11.38	0.74 ± 0.12	+61.30 ± 4.91