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Journal of Nanomaterials
Volume 2013, Article ID 763937, 8 pages
Research Article

Osteogenesis Capability and Degradation Property Evaluation of Injectable Biomaterials: Comparison of Computed Tomography and Ultrasound

1Department of Ultrasonic Diagnosis, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China
2The Second Clinical Medical College of Southern Medical University, Guangzhou 510282, China
3Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
4Department of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China
5Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China

Received 19 May 2013; Accepted 17 June 2013

Academic Editor: Shuming Zhang

Copyright © 2013 Yan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Injectable biomaterials, which can be physically inserted into a target site without the use of surgery, have received increasing attention in tissue engineering during the last decade. There is also a growing need for quantitative evaluation of the injectable biomaterial directly and noninvasively. The objectives of this study are to originate a quantitative noninvasive technique for evaluation of in situ forming bone biomaterials and to validate the feasibility of diagnostic ultrasound images analysis technique. The potential of ultrasound for quantitative evaluation of tissue development was compared with computed tomography (CT) in vivo. A strong correlation was witnessed between ultrasound gray-scale values (GV) and volumetric mean of CT value ( ) ( ). Meanwhile, the volume of the material area could be estimated by ultrasound maximum cross-section pixel, which demonstrates a certain consistency with CT mask volume in 3D reconstruction images ( ). In conclusion, ultrasound imaging, which is corresponding with the traditional CT, can be used to evaluate osteogenesis capability and degradation property of injectable biomaterials. It may be a noninvasive, nonradioactive, and effective aid to monitor ossification and reconstruction of biomaterials at the implant region for bone defect repair.