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Journal of Nanomaterials
Volume 2013, Article ID 768628, 9 pages
http://dx.doi.org/10.1155/2013/768628
Research Article

Preparation and Biological Properties of Platinum(II) Complex-Loaded Copolymer PLA-TPGS

1Institute of Materials Science, Hanoi 844, Vietnam
2Vinh University, Vinh 8438, Vietnam
3Institute of Natural Products Chemistry, Hanoi 844, Vietnam

Received 1 August 2013; Revised 20 October 2013; Accepted 20 October 2013

Academic Editor: Abdelwahab Omri

Copyright © 2013 Ha Phuong Thu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new nanodrug system containing bis(menthone thiosemicarbazonato) Platinum(II) complex (Pt-thiomen) encapsulated with the block copolymers polylactide-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) was prepared by a modified solvent extraction/evaporation technique. The characteristics of the nanoparticles including surface morphology, size distribution, structure, and biological activities such as antimicrobial and cytotoxic activities were in vitro investigated. The spherical nanoparticles were around 50 nm in size with core-shell structure and narrow-size distribution. The encapsulated Pt-thiomen can avoid interaction with proteins in the blood plasma. The inhibitory activity of Pt-thiomen-loaded PLA-TPGS nanoparticles on the growth of some bacteria, fungi, and Hep-G2 cells suggests a possibility of developing PLA-TPGS-Pt-thiomen nanoparticles as one of the potential chemotherapeutic agents.