Journal of Nanomaterials / 2013 / Article / Tab 1

Review Article

A Review of the Effect of Processing Variables on the Fabrication of Electrospun Nanofibers for Drug Delivery Applications

Table 1

Solvent properties and the resulting fiber morphology.

SolventBoiling point (°C)Other propertiesFiber morphologyRef.

DCM39.8Low dielectric constant, high surface tensionBeaded, large diameter[77, 85]
Chloroform61.2High intrinsic viscosityBeaded at very low polymer concentration, smooth at higher concentration[86]
Methanol64.7High dielectric constantSmall fiber diameter with ↑ methanol concentration until 50% then ↑ fiber diameter[77]
THF66High dipole moment, good conductivitySmooth and beaded, ribbon-like, high pore density[78, 87]
Ethyl acetate77.1High dielectric constant, fair conductivitySmooth and beaded, ribbon-like[87]
Ethanol78.3Low surface tension, high intrinsic viscositySmooth, large diameter[83, 85, 86]
MEK79.6High dipole moment, good conductivityFlat, ribbon-like, very few beads[87]
Dichloroethane83.5High dipole moment, fair conductivitySmooth and beaded, C-shaped[87]
Water100Low intrinsic viscosityBeaded, small diameter[83, 86]
DMF153High dipole moment, high conductivity, low intrinsic viscositySmooth and beaded, round[86, 87]

(DCM: dichloromethane; THF: tetrahydrofuran; MEK: methyl ethyl ketone; DMF: dimethylformamide).

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