Nanotechnological Advances in Cutaneous Medicine

Table 1

The use of nanoparticle technology for delivery of drugs transcutaneously targeting the most common cutaneous pathologies.

Nanoparticle type	Drug	Skin type	Study	Delivery type and penetration	Targeted cutaneous disease pathology	Literature studies
Solid lipid nanoparticle	Glucocorticoids, corticosteroids	Human	In vitro and in vivo	Transepidermal delivery, no penetration to the dermis	Inflammatory skin diseases, dermatitis, rheumatic disease	Sivaramakrishnan et al., 2004 [24]; Jensen et al., 2010 [25]; Zhang and Smith, 2011 [26]; Schlupp et al., 2011 [27]; Puglia et al., 2006 [28]
Solid lipid nanoparticle	Nonsteroidal anti-inflammatory drugs	Human	In vitro and in vivo	Delivery via NP enriched hydrogels with sustained continued drug release to the dermis	Musculoskeletal disorders	Jain et al., 2005 [29]; Bhaskar et al., 2009 [30]
Solid lipid nanoparticle	Antiandrogens, retinoids	Human	In vitro and in vivo	Transappendageal NP delivery to hair follicle and upper papillary dermis	Skin acne	Munster et al., 2005 [31]; Štecová et al., 2007 [32]; Castro et al., 2007 [33]
Solid lipid nanoparticle	Antifungal agents	Human	Ex vivo and in vivo	Topical gel delivery of NP with penetration to upper papillary dermis	Skin mycoses	Bhalekar et al., 2009 [34]; Sanna et al., 2007 [35]
Solid lipid nanoparticle	Retinoids, furocoumarins	Mouse and human	In vivo	Topical gel delivery to the epidermis	Psoriasis	Fang et al., 2008 [19]; Agrawal et al., 2010 [15]; Lin et al., 2010 [36]
Solid lipid nanoparticle	Tacrolimus	Porcine	In vitro and in vivo	Topical gel delivery with dermal penetration	Atopic dermatitis	Pople and Singh, 2010 [37]
Nanostructured lipid carriers	Antihypersensitive drugs and anaesthetics	Mouse and human	In vitro and in vivo	Topical gel delivery to the epidermis	Hair loss treatment and pain relief after surgery	Silva et al., 2009 [38]; Puglia et al., 2011 [39]