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Journal of Nanomaterials
Volume 2013, Article ID 864584, 6 pages
http://dx.doi.org/10.1155/2013/864584
Research Article

Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

1Nanoscience and Nanotechnology Program, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
2Department of Physics and KAUST-HKUST Joint Micro/Nanofluidic Laboratory, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
3Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, China

Received 2 July 2013; Accepted 25 August 2013

Academic Editor: Krasimir Vasilev

Copyright © 2013 Xiang Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.