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  1. X. Zhang, M. Xu, X. Liu et al., “Restoration of critical-sized defects in the rabbit mandible using autologous bone marrow stromal cells hybridized with nano-β-tricalcium phosphate/collagen scaffolds,” Journal of Nanomaterials, vol. 2013, Article ID 913438, 8 pages, 2013.
Journal of Nanomaterials
Volume 2013, Article ID 913438, 8 pages
Research Article

Restoration of Critical-Sized Defects in the Rabbit Mandible Using Autologous Bone Marrow Stromal Cells Hybridized with Nano-β-tricalcium Phosphate/Collagen Scaffolds

1Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
2State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
3The Oral Clinic of the 2nd Hospital of Beijing Armed Police Force, Beijing 100037, China
4National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China

Received 26 July 2013; Accepted 26 September 2013

Academic Editor: Haifeng Chen

Copyright © 2013 Xuehui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nano-β-tricalcium phosphate/collagen (n-β-TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n-β-TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n-β-TCP/Col scaffolds exhibited high biocompatibility in vitro. The introduction of BMSCs expanded in vitro to the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n-β-TCP/Col scaffolds have the potential to be applied in bone tissue engineering.