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Journal of Nanomaterials
Volume 2014, Article ID 276057, 5 pages
http://dx.doi.org/10.1155/2014/276057
Research Article

A Turn-On Fluorescent Probe for Detecting Nitric Oxide in Aqueous Media

Advanced Materials Convergence Division, Korea Institute of Ceramic Engineering and Technology, Seoul, Republic of Korea

Received 24 September 2014; Accepted 4 December 2014; Published 25 December 2014

Academic Editor: Jung Y. Huang

Copyright © 2014 Eunhae Koo and Jong-Chul Lee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Imaging of nitric oxide (NO) in living cells can provide new insights in understanding unsolved pathways in the cardiovascular and neurological dysfunction and many types of cancers. For the detection of NO under physiological conditions, we synthesized a turn-on fluorescent probe comprising CdSe/ZnS quantum dots (QDs) coordinated with dirhodium complex. Emission from CdSe/ZnS-QDs is quenched when coordinated with the dirhodium complex but can be restored upon the displacement by nitric oxide.