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Journal of Nanomaterials
Volume 2014 (2014), Article ID 853120, 8 pages
http://dx.doi.org/10.1155/2014/853120
Research Article

The Effect of Silver Nanofibers on the Deformation Properties of Blood Vessels: Towards the Development of New Nanotechnologies to Prevent Rupture of Aneurysms

1 Department of Chemistry, Chemical Imaging Center, The University of Puerto Rico at Mayaguez, Mayaguez, PR 00682, USA
2University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA

Received 30 October 2013; Revised 10 January 2014; Accepted 9 February 2014; Published 15 May 2014

Academic Editor: Jingxia Wang

Copyright © 2014 Miguel Gonzalez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An aneurysm is the result of a widening or ballooning of a portion of a blood vessel. The rupture of an aneurysm occurs when the mechanical stress acting on the inner wall exceeds the failure strength of the blood vessel. We propose an innovative approach to prevent the rupture of an aneurysm based on the use of nanotechnology to improve the strength of the blood vessel. We present results on the effect of silver nanofibers on the resistance toward deformation of blood vessels. The silver nanofibers are grown on the surface of the blood vessels. The nanofibers are  nm in diameter and μm in length. The deformation per applied force of blood vessels was found to decrease from 0.15 m/N in control blood vessels to 0.003 m/N in blood vessels treated with the nanofibers. This represents an increase in the resistance towards deformation of a factor of 50. The increase in the resistance towards deformation is clinically significant since blood pressure increases by factors slightly larger than one in the human body. Treatment of blood vessels with silver nanofibers is a potential translational clinical tool for preventing rupture of aneurysms in a clinical setting.