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Journal of Nanomaterials
Volume 2014 (2014), Article ID 853967, 8 pages
http://dx.doi.org/10.1155/2014/853967
Research Article

An Alcohol-Free SiO2 Sol-Gel Matrix Functionalized with Acetic Acid as Drug Reservoir for the Controlled Release of Pentoxifylline

1División Académica de Ingeniería y Arquitectura, Universidad Juárez Autónoma de Tabasco, Carr. Cunduacán-Jalpa de Méndez Km. 1, Colonia La Esmeralda, 86690 Cunduacán, TAB, Mexico
2Laboratorio de Microscopía Electrónica, Instituto Nacional de Rehabilitación, Calz. México-Xochimilco 289, Colonia Arenal de Guadalupe, 14389 Tlalpan, D.F., Mexico

Received 14 March 2014; Revised 22 May 2014; Accepted 22 May 2014; Published 6 July 2014

Academic Editor: Zhongkui Hong

Copyright © 2014 Mayra Angélica Alvarez Lemus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pentoxifylline (PTX) is a xanthine derivative, with hemorrheologic properties, that has been useful in the treatment of several diseases. However, a conventional route of administration implies high doses, what is unnecessary to the organism, seriously increasing the risk of toxicity because of side effects. Because of the facility to modify their surface, sol-gel materials have proved to be suitable reservoirs for a variety of molecules for biological applications. In this work we prepared alcohol-free SiO2 material by the sol-gel process using acetic acid as surface modifier and hydrolysis catalyst, the alkoxide/water ratio (Rw) used was 1/16, and tetraethylorthosilicate was used as SiO2 precursor. Spectroscopic characterization was carried out by means of FTIR-ATR and UV-Visible spectroscopies; the results confirmed the presence of the drug and interactions between sol-gel matrix and PTX. BET specific surface area values of the sol-gel materials were 365 and 462 m2/g for SiO2 and PTX-SiO2, respectively. Synthesized SiO2 nanoparticles showed efficient entrapment of PTX since a controlled release of 83% of drug content was reached.