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Journal of Nanomaterials
Volume 2015, Article ID 101464, 4 pages
Research Article

Experimental Study on the Components in Polyvalent “Ghost” Salmonella Vaccine for Veterinary Use

1BB-NCIPD, 26 Yanko Sakazov Boulevard, 1504 Sofia, Bulgaria
2Faculty of Biology, Sofia University “St. Kliment Ohridski”, 8 Dragan Tsankov Boulevard, 1164 Sofia, Bulgaria
3Veterinary Clinic “Zoocenter”, 1799 Sofia, Bulgaria
4National Centre of Infectious and Parasitic Diseases, 26 Yanko Sakazov Boulevard, 1504 Sofia, Bulgaria
5UCTM, 8 “St. Kliment Ohridski” Boulevard, 1756 Sofia, Bulgaria

Received 19 March 2015; Revised 26 June 2015; Accepted 28 June 2015

Academic Editor: Abdelwahab Omri

Copyright © 2015 Daniela Vasileva Pencheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Development of “ghost” Salmonella vaccines, inactivated by using a hybrid nanomaterial based on silver nanoparticles (AgNps) stabilized via polyvinyl alcohol (PVA), is an innovative approach in vaccine production. For this purpose, a series of attempts to establish the components of the polyvalent “ghost” Salmonella vaccine and the most suitable methods for its preparation were performed. The following strains S. Enteritidis, S. Newport-Puerto Rico, and S. Typhimurium were chosen as appropriate candidates for their incorporation in order to create polyvalent Salmonella “ghost” vaccine for veterinary use.