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Journal of Nanomaterials
Volume 2015, Article ID 154592, 12 pages
Review Article

Mussel-Inspired Polydopamine Coated Iron Oxide Nanoparticles for Biomedical Application

Shandong Provincal Engineering Laboratory of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, Dezhou University, Dezhou 253023, China

Received 16 October 2014; Revised 25 December 2014; Accepted 25 December 2014

Academic Editor: William W. Yu

Copyright © 2015 Xiangling Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mussel-inspired polydopamine (PDA) coated iron oxide nanoparticles have served as a feasible, robust, and functional platform for various biomedical applications. However, there is scarcely a systemic paper reviewed about such functionalising nanomaterials to date. In this review, the synthesis of iron oxide nanoparticles, the mechanism of dopamine self-oxidation, the interaction between iron oxide and dopamine, and the functionality and the safety assessment of dopamine modified iron oxide nanoparticles as well as the biomedical application of such nanoparticles are discussed. To enlighten the future research, the opportunities and the limitations of functionalising iron oxide nanoparticles coated with PDA are also analyzed.