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Journal of Nanomaterials
Volume 2015, Article ID 163190, 9 pages
Research Article

Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite

Department of Chemical Engineering, Soongsil University, Seoul 156-743, Republic of Korea

Received 4 July 2014; Accepted 3 September 2014

Academic Editor: Xinqing Chen

Copyright © 2015 Kyoung A Cho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mesocrystal formation is one of the new paradigms of the nonclassical crystallization, where the assembly of crystal domains is observed. Also, it has been recently employed in studies on drug formulation to utilize controlled dissolution of the drug domains. In this report, ibuprofen was attempted to form hybrid mesocrystals with calcium carbonate crystals. Two polymorphs of calcium carbonate (aragonite and calcite) were used during the solid-state process of ball milling. Structural analyses confirmed the mesocrystal formation of ibuprofen with aragonite but not with calcite. The origin of the observed behavior was found from the higher affinity of ibuprofen to aragonite, especially its (0 1 0) surface, compared to calcite. The hybrid mesocrystals of ibuprofen and aragonite showed the environment-responsive release behavior, where the stability of aragonite was the controlling factor for the release kinetics of ibuprofen.