Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2015, Article ID 303426, 10 pages
http://dx.doi.org/10.1155/2015/303426
Research Article

In Vitro Biological Evaluation of Electrospun Polycaprolactone/Gelatine Nanofibrous Scaffold for Tissue Engineering

1Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), Skudai, 81310 Johor, Malaysia
2Miniaturized Medical Devices Program, Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR), Singapore
3Advanced Membrane Technology Research Center, Universiti Teknologi Malaysia (UTM), Skudai, 81310 Johor, Malaysia

Received 17 September 2015; Accepted 22 November 2015

Academic Editor: Shafiul Chowdhury

Copyright © 2015 Mim Mim Lim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Sun, T. H. Khan, and N. Sultana, “Fabrication and in vitro evaluation of nanosized hydroxyapatite/chitosan-based tissue engineering scaffolds,” Journal of Nanomaterials, vol. 2014, Article ID 194680, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. M. I. Hassan, T. Sun, and N. Sultana, “Fabrication of nanohydroxyapatite/poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications,” Journal of Nanomaterials, vol. 2014, Article ID 209049, 7 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Roozbahani, N. Sultana, A. F. Ismail, and H. Nouparvar, “Effects of chitosan alkali pretreatment on the preparation of electrospun PCL/chitosan blend nanofibrous scaffolds for tissue engineering application,” Journal of Nanomaterials, vol. 2013, Article ID 641502, 6 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. V. K. Bulasara, R. Uppaluri, and M. K. Purkait, “Manufacture of nickel-ceramic composite membranes in agitated electroless plating baths,” Materials and Manufacturing Processes, vol. 26, no. 6, pp. 862–867, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. P. Prabhakaran, J. R. Venugopal, T. T. Chyan et al., “Electrospun biocomposite nanofibrous scaffolds for neural tissue engineering,” Tissue Engineering Part: A, vol. 14, no. 11, pp. 1787–1797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Puppi, N. Detta, A. M. Piras et al., “Development of electrospun three-arm star poly(ε-caprolactone) meshes for tissue engineering applications,” Macromolecular Bioscience, vol. 10, no. 8, pp. 887–897, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Mota, D. Puppi, M. Gazzarri, P. Bártolo, and F. Chiellini, “Melt electrospinning writing of three-dimensional star poly(ϵ-caprolactone) scaffolds,” Polymer International, vol. 62, no. 6, pp. 893–900, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Detta, C. Errico, D. Dinucci et al., “Novel electrospun polyurethane/gelatin composite meshes for vascular grafts,” Journal of Materials Science: Materials in Medicine, vol. 21, no. 5, pp. 1761–1769, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. L. H. Chong, M. M. Lim, and N. Sultana, “Fabrication and evaluation of polycaprolactone/gelatin-based electrospun nanofibers with antibacterial properties,” Journal of Nanomaterials, vol. 2015, Article ID 970542, 8 pages, 2015. View at Publisher · View at Google Scholar
  10. M. Abedalwafa, F. Wang, L. Wang, and C. Li, “Biodegradable poly-epsilon-caprolactone (PCL) for tissue engineering applications: a review,” Reviews on Advanced Materials Science, vol. 34, no. 2, pp. 123–140, 2013. View at Google Scholar · View at Scopus
  11. GMIA, Gelatin Handbook, Gelatin Manufacturers Institute of America, 2012.
  12. L. Jeong and W. H. Park, “Preparation and characterization of gelatin nanofibers containing silver nanoparticles,” International Journal of Molecular Sciences, vol. 15, no. 4, pp. 6857–6879, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Van der Schueren, B. De Schoenmaker, Ö. I. Kalaoglu, and K. De Clerck, “An alternative solvent system for the steady state electrospinning of polycaprolactone,” European Polymer Journal, vol. 47, no. 6, pp. 1256–1263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Ghasemi-Mobarakeh, M. P. Prabhakaran, M. Morshed, M.-H. Nasr-Esfahani, and S. Ramakrishna, “Electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering,” Biomaterials, vol. 29, no. 34, pp. 4532–4539, 2008. View at Publisher · View at Google Scholar
  15. H. Shimizu, Shimizu's Textbook of Dermatology, Hokkaido University, 2007.
  16. E. J. Chong, T. T. Phan, I. J. Lim et al., “Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution,” Acta Biomaterialia, vol. 3, no. 3, pp. 321–330, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Zhang, H. Ouyang, T. L. Chwee, S. Ramakrishna, and Z.-M. Huang, “Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds,” Journal of Biomedical Materials Research Part B Applied Biomaterials, vol. 72, no. 1, pp. 156–165, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Xu, F. Yang, S. Wang, and S. Ramakrishna, “In vitro study of human vascular endothelial cell function on materials with various surface roughness,” Journal of Biomedical Materials Research Part A, vol. 71, no. 1, pp. 154–161, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. SCOGS DFs, “FDA’s SCOGS database,” Gelatin, Contract No. 58, 1975.
  20. E. Schnell, K. Klinkhammer, S. Balzer et al., “Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-ε-caprolactone and a collagen/poly-ε-caprolactone blend,” Biomaterials, vol. 28, no. 19, pp. 3012–3025, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Lubasová, L. Martinová, D. Martinová, and P. Kostecká, “Cell growth on porous and non-porous polycaprolactone nanofibers,” in Proceedings of the International Conference on Nano Technology (NANOCON '10), October 2010.
  22. M.-S. Khil, S. R. Bhattarai, H.-Y. Kim, S.-Z. Kim, and K.-H. Lee, “Novel fabricated matrix via electrospinning for tissue engineering,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 72, no. 1, pp. 117–124, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. Ma, Z. Mao, and C. Gao, “Surface modification and property analysis of biomedical polymers used for tissue engineering,” Colloids and Surfaces B: Biointerfaces, vol. 60, no. 2, pp. 137–157, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. R. A. Freitas, “Nanomedicine,” in Basic Capabilities, vol. 1, Landes Bioscience, Georgetown, Tex, USA, 1999. View at Google Scholar