Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2015, Article ID 340981, 7 pages
http://dx.doi.org/10.1155/2015/340981
Research Article

Development of a Composite Electrospun Polyethylene Terephthalate-Polyglycolic Acid Material: Potential Use as a Drug-Eluting Vascular Graft

1Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
2BioSurfaces, Inc., Ashland, MA 01721, USA
3Harvard School of Engineering and Applied Sciences, Cambridge, MA 02138, USA
4Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

Received 15 April 2015; Revised 24 July 2015; Accepted 3 August 2015

Academic Editor: Mircea Chipara

Copyright © 2015 Christoph S. Nabzdyk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. S. Sottiurai, J. S. T. Yao, W. R. Flinn, and R. C. Batson, “Intimal hyperplasia and neointima: an ultrastructural analysis of thrombosed grafts in humans,” Surgery, vol. 93, no. 6, pp. 809–817, 1983. View at Google Scholar · View at Scopus
  2. C. S. Nabzdyk, M. C. Chun, H. S. Oliver-Allen et al., “Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts,” Biomaterials, vol. 35, no. 9, pp. 3071–3079, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Wang, X. M. Mo, B. J. Jiang et al., “Fabrication of small-diameter vascular scaffolds by heparin-bonded P(LLA-CL) composite nanofibers to improve graft patency,” International Journal of Nanomedicine, vol. 8, pp. 2131–2139, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Han, S. Farah, A. J. Domb, and P. I. Lelkes, “Electrospun rapamycin-eluting polyurethane fibers for vascular grafts,” Pharmaceutical Research, vol. 30, no. 7, pp. 1735–1748, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Cagiannos, O. R. Abul-Khoudoud, W. DeRijk et al., “Rapamycin-coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model,” Journal of Vascular Surgery, vol. 42, no. 5, pp. 980–988, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Bhasin, Z. Huang, L. Pradhan-Nabzdyk et al., “Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury,” PLoS ONE, vol. 7, no. 6, Article ID e39123, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl, “Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells,” Nature, vol. 411, no. 6836, pp. 494–498, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. C. S. Nabzdyk, H. Lancero, K. P. Nguyen, S. Salek, and M. S. Conte, “RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 301, no. 5, pp. H1841–H1849, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Pradhan-Nabzdyk, C. Huang, F. W. LoGerfo, and C. S. Nabzdyk, “Current siRNA targets in atherosclerosis and aortic aneurysm,” Discovery Medicine, vol. 17, no. 95, pp. 233–246, 2014. View at Google Scholar
  10. S. Yoshida, C. S. Nabzdyk, L. Pradhan, and F. W. Logerfo, “Thrombospondin-2 gene silencing in human aortic smooth muscle cells improves cell attachment,” Journal of the American College of Surgeons, vol. 213, no. 5, pp. 668–676, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Chung, N. P. Ingle, G. A. Montero, S. H. Kim, and M. W. King, “Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning,” Acta Biomaterialia, vol. 6, no. 6, pp. 1958–1967, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Chen, S. Gao, M. Dong et al., “Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery,” ACS Nano, vol. 6, no. 6, pp. 4835–4844, 2012. View at Publisher · View at Google Scholar · View at Scopus