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Journal of Nanomaterials
Volume 2015, Article ID 380326, 9 pages
Research Article

Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion

1Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
2Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100081, China
3Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China
4National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China
5Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China

Received 22 May 2015; Revised 20 August 2015; Accepted 20 August 2015

Academic Editor: Anh-Tuan Le

Copyright © 2015 Qianqian Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim was to evaluate the remineralizing efficacy of fluorohydroxyapatite (FHA) gel on artificial dentinal caries lesion in vitro. Artificial carious lesions were made on occlusal cavities of teeth by exposing the dentin surface to a demineralizing solution. Each cavity was capped with a 3 mm thick FHA gel for 4 weeks. After the FHA gel was removed, the surface morphology and structure of the dentin were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The dentin mineral density (DMD) was measured by micro-computed tomography (Micro-CT). A layer of dense and orderly hexagonal crystal structure, with average diameter of 1 μm and thickness of 4~5 μm, could be observed on dentin surface. These crystals exhibited elemental peaks for calcium, phosphorus, carbon, and oxygen and characteristic peaks of hydroxyapatite (HA) and fluorapatite (FA) via XRD and FT-IR. The DMD of dentin surface layer significantly increased after it was capped with FHA gel (). In the present study, the FHA gel could rapidly construct apatite on the artificial dentin caries surface and significantly increase the mineral density, which suggests that FHA gel might be a proper IPT material with remineralizing function.