Ultra-Sensitive Colorimetric Plasmonic Sensing and Microfluidics for Biofluid Diagnostics Using Nanohole Array

Figure 14

Surface functionalization and detection of biomolecules using nanohole array sensor. (a) Typical surface modification of nanohole array sensor for specific recognition of biomolecule. The surface is modified with a monolayer of linker (DSU) and antibodies (PAX8). (b) Intensity variation due to the presence of increasing concentrations of antibodies on the surface of the nanohole array sensor. Modified from [77]. (c) Colorimetric variations due to difference concentrations of target and probe DNA strands immobilized from nanohole array sensor. Modified from [46]. (d) Peak wavelength shift due to the nonspecific attachment of bovine serum albumin on a nanohole array sensor. Modified from [93].

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