Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery

Table 1

Change of liposomal size and drug EE of PEGylated and folate-PEGylated liposomes containing Ptx various molar ratios of DSPE-mPEG^#.

Molar ratio of DSPE-mPEG	Liposomal size (nm)		Encapsulation efficiency (%)
	PEGylated liposome	Folate-PEGylated liposome	PEGylated liposome	Folate-PEGylated liposome
0	224 ± 21.8	224 ± 21.8	76 ± 1.8	76 ± 1.8
1	148 ± 3.65^∗	140 ± 9.79^∗	78 ± 3.6	77 ± 1.3
2	123 ± 10.2^∗	126 ± 6.65^∗	79 ± 2.7	82 ± 1.2^∗
3	114 ± 6.81^∗	122 ± 4.87^∗	81 ± 2.3^∗	88 ± 2.0^∗
4	121 ± 20.0^∗	125 ± 3.40^∗	83 ± 4.8^∗	68 ± 1.3^∗

Mean ± S.D. ( = 5). < 0.05 between 0 and specific molar ratio of DSPE-mPEG.