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Journal of Nanomaterials
Volume 2015 (2015), Article ID 581713, 11 pages
http://dx.doi.org/10.1155/2015/581713
Research Article

The Evaluation of Osseointegration of Dental Implant Surface with Different Size of TiO2 Nanotube in Rats

1Department of Prosthodontics, Oral Science Research Center, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea
2Department of Prosthodontics, Gangnam Severance Dental Hospital, Eonju-ro 612, Gangnam-gu, Seoul 135-720, Republic of Korea
3Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea
4Department of Dental Biomaterials, Institute of Biomaterials-Implant, Wonkwang University School of Dentistry, 460 Iksandae-ro, Iksan 570-749, Republic of Korea

Received 25 July 2014; Accepted 21 October 2014

Academic Editor: Sungtae Kim

Copyright © 2015 Young-Ah Yi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

With the development of nanotechnology, many researches have shown that nanometer-scaled materials especially TiO2 nanotube have a positive effect on cellular behavior and surface characteristics of implant, which are considered to be crucial factors in osseointegration. However, it has not yet been verified which nanotube size is effective in osseointegration in vivo. The aim of this study was to evaluate the effect of implant surface-treated with different size of TiO2 nanotubes on osseointegration in rat femur. The customized implants (threaded and nonthreaded type), surface-treated with different diameter of TiO2 nanotubes (30 nm, 50 nm, 70 nm, and 100 nm nanotube), were placed on both sides of the femur of 50 male Sprague-Dawley rats (6 weeks old). Rats were sacrificed at 2 and 6 weeks following surgery; then the specimens were collected by perfusion fixation and the osseointegration of implants was evaluated by radiographic and histologic analyses and removal torque value test. The mean of bone area (%) and the mean of removal torque were different in each group, indicating that the difference in TiO2 nanotube size may influence new bone formation and osseointegration in rats.