Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100/RS100 for Anti-Colon Cancer Drug Delivery

Table 2

Effect of the E-RL100 : E-RS100 ratio on NPs characteristics. NPs were prepared without surfactants at 20% drug loading and various E-RL100 : E-RS100 ratios. The solvent was evaporated, the free drug was removed by filtration, and the entrapment efficiency, particle size, polydispersity index, zeta potential, and percentage yield were determined. The results are depicted as average ± SD ().

Formulation	E-RL100 : E-RS100 (wt/wt)	E. efficiency (%)	P. size (nm)	Polydispersity index	Z. potential (mV)	Yield (%)
F1	0 : 1	96.0 ± 7.0	72.0 ± 0.4	0.21 ± 0.01	34.0 ± 0.7	86 ± 0.1
F2	1 : 3	96.0 ± 6.0	77.0 ± 0.6	0.19 ± 0.01	32.0 ± 0.9	92 ± 0.1
F3	1 : 1	101.0 ± 1.0	65.0 ± 0.4	0.20 ± 0.00	34.0 ± 2.9	98 ± 0.2
F4	3 : 1	94.0 ± 0.1	45.0 ± 0.3	0.19 ± 0.01	31.0 ± 1.0	99 ± 0.3
F5	1 : 0	98.0 ± 1.0	46.0 ± 0.1	0.21 ± 0.00	30.0 ± 1.4	91 ± 0.3