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Journal of Nanomaterials
Volume 2015, Article ID 704789, 8 pages
http://dx.doi.org/10.1155/2015/704789
Research Article

Autophagy in RAW264.7 Cells Treated with Surface-Functionalized Graphene Oxides

1Department of Internal Medicine, Chung-Ang University College of Medicine, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Republic of Korea
2School of Chemical Engineering and Materials Science, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Republic of Korea

Received 19 May 2015; Accepted 21 July 2015

Academic Editor: Jin W. Seo

Copyright © 2015 Chang Seok Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Orecchioni, D. Bedognetti, F. Sgarrella, F. M. Marincola, A. Bianco, and L. G. Delogu, “Impact of carbon nanotubes and graphene on immune cells,” Journal of Translational Medicine, vol. 12, no. 1, article no. 138, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. K. C. Kwon, K. S. Choi, B. J. Kim, J.-L. Lee, and S. Y. Kim, “Work-function decrease of graphene sheet using alkali metal carbonates,” The Journal of Physical Chemistry C, vol. 116, no. 50, pp. 26586–26591, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Sun, J. Chao, J. Huang et al., “Uniform small graphene oxide as an efficient cellular nanocarrier for immunostimulatory CpG oligonucleotides,” ACS Applied Materials & Interfaces, vol. 6, no. 10, pp. 7926–7932, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Bussy, H. Ali-Boucetta, and K. Kostarelos, “Safety considerations for graphene: lessons learnt from carbon nanotubes,” Accounts of Chemical Research, vol. 46, no. 3, pp. 692–701, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Li, L. Feng, X. Shi et al., “Surface coating-dependent cytotoxicity and degradation of graphene derivatives: towards the design of non-toxic, degradable nano-graphene,” Small, vol. 10, no. 8, pp. 1544–1554, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Wan, Z.-X. Wang, Q.-Y. Lv et al., “Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages,” Toxicology Letters, vol. 221, no. 2, pp. 118–127, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Y. Lee, Q. V. Le, C. Kim, and S. Y. Kim, “Use of silane-functionalized graphene oxide in organic photovoltaic cells and organic light-emitting diodes,” Physical Chemistry Chemical Physics, vol. 17, no. 14, pp. 9369–9374, 2015. View at Publisher · View at Google Scholar
  8. H. Wang, Q. Hao, X. Yang, L. Lu, and X. Wang, “Effect of graphene oxide on the properties of its composite with polyaniline,” ACS Applied Materials and Interfaces, vol. 2, no. 3, pp. 821–828, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Kuila, P. Khanra, A. K. Mishra, N. H. Kim, and J. H. Lee, “Functionalized-graphene/ethylene vinyl acetate co-polymer composites for improved mechanical and thermal properties,” Polymer Testing, vol. 31, no. 2, pp. 282–289, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Wang, X. Shen, B. Wang, J. Yao, and J. Park, “Synthesis and characterisation of hydrophilic and organophilic graphene nanosheets,” Carbon, vol. 47, no. 5, pp. 1359–1364, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. J. H. Shin, S. G. Han, J. K. Kim et al., “5-Day repeated inhalation and 28-day post-exposure study of graphene,” Nanotoxicology, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  12. M. Zhang, M. Yang, C. Bussy, S. Iijima, K. Kostarelos, and M. Yudasaka, “Biodegradation of carbon nanohorns in macrophage cells,” Nanoscale, vol. 7, no. 7, pp. 2834–2840, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Luo, D. Ni, H. Yue, W. Wei, and G. Ma, “Surface-engineered graphene navigate divergent biological outcomes toward macrophages,” ACS Applied Materials & Interfaces, vol. 7, no. 9, pp. 5239–5247, 2015. View at Publisher · View at Google Scholar
  14. J. Linares, M. C. Matesanz, M. Vila et al., “Endocytic mechanisms of graphene oxide nanosheets in osteoblasts, hepatocytes and macrophages,” ACS Applied Materials & Interfaces, vol. 6, no. 16, pp. 13697–13706, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Volarevic, V. Paunovic, Z. Markovic et al., “Large graphene quantum dots alleviate immune-mediated liver damage,” ACS Nano, vol. 8, no. 12, pp. 12098–12109, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Qin, Z.-W. Zhou, S.-T. Pan et al., “Graphene quantum dots induce apoptosis, autophagy, and inflammatory response via p38 mitogen-activated protein kinase and nuclear factor-κB mediated signaling pathways in activated THP-1 macrophages,” Toxicology, vol. 327, pp. 62–76, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. M. J. Feito, M. Vila, M. C. Matesanz et al., “In vitro evaluation of graphene oxide nanosheets on immune function,” Journal of Colloid and Interface Science, vol. 432, pp. 221–228, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Glick, S. Barth, and K. F. Macleod, “Autophagy: cellular and molecular mechanisms,” The Journal of Pathology, vol. 221, no. 1, pp. 3–12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Haimovici, D. Brigger, B. E. Torbett, M. F. Fey, and M. P. Tschan, “Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation,” Leukemia Research, vol. 38, no. 9, pp. 1041–1047, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Brigger, T. Proikas-Cezanne, and M. P. Tschan, “WIPI-Dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells,” Cell Death & Disease, vol. 5, no. 7, Article ID e1315, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Ueno, H. Tatetsu, H. Hata et al., “PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL,” Oncogene, vol. 28, no. 46, pp. 4116–4125, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Zhao, X.-F. Duan, D.-H. Wen, and G.-Q. Chen, “PU.1, a novel capase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells,” Biochemical and Biophysical Research Communications, vol. 382, no. 3, pp. 508–513, 2009. View at Publisher · View at Google Scholar · View at Scopus