Multifunctional DNA Nanomaterials for Biomedical Applications

Table 1

Stability of different DNA nanostructures.

	Linear dsDNA	CpGbearing; DNA tetrahedral nanostructure	A 3D multilayer rectangular; parallelepiped structure
Description of the structure	Normal linear DNA strand with DdeI restriction site	It is made up of four 55-mer strands extended with the CpG sequence and a 7-mer oligothymine spacer	A 3D multilayer rectangular; parallelepiped structure (8 helix × 8 helix square lattice with; dimensions of 16 nm × 16 nm × 30 nm)
Incubation temperature	/	37°C	25°C
Medium	10% FBS	50% non-heat-inactivated fetal bovine serum (FBS)	Cell lysate
Decay time	Decay after 0.8 h	Start decaying after 4 h, but still not completely decayed after 24 h	Still remains stable after 12 h
Citation	[41]	[43]	[44]