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Journal of Nanomaterials
Volume 2015, Article ID 818565, 9 pages
Research Article

The Promotion of Antibacterial Effects of Ti6Al4V Alloy Modified with TiO2 Nanotubes Using a Superoxidized Solution

1Facultad de Odontología Mexicali, Universidad Autónoma de Baja California, Avenida Zotoluca y Chinampas, s/n, 21040 Mexicali, BC, Mexico
2Instituto de Ingeniería, Universidad Autónoma de Baja California, Boulevard B. Juárez y Calle de la Normal s/n, 21280 Mexicali, BC, Mexico
3University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
4Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 México, DF, Mexico
5Centro Medico Ixchel, Bravo y Obregón, 21000 Mexicali, BC, Mexico

Received 18 February 2015; Revised 9 April 2015; Accepted 20 April 2015

Academic Editor: P. Davide Cozzoli

Copyright © 2015 Ernesto Beltrán-Partida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of the present study was to synthetize 80 nm diameter TiO2 nanotubes (NTs) on Ti6Al4V alloy using a commercially superoxidized water (SOW) enriched with fluoride to reduce anodization time and promote the antibacterial efficacy against Staphylococcus aureus (S. aureus). The alloy discs were anodized for 5 min and as a result, NTs of approximately 80 nm diameters were obtained with similar morphology as reported in previous studies using longer anodization times (1-2 h). Filed emission-scanning electron microscopy (FE-SEM) and energy dispersive X-ray spectroscopy (EDX) were used to characterize the materials surfaces. The NTs showed significantly decreased S. aureus viability after 1, 3, and 5 days of culture in comparison to nonanodized alloy. Likewise, SEM analysis also suggested lower bacterial adhesion on the NTs surface. No differences in bacterial morphology and topography were observed on both materials, as analyzed by SEM and atomic force microscopy (AFM). In conclusion, 80 nm diameter NTs were grown on Ti6Al4V alloy in 5 min by using a SOW solution enriched with fluoride, which resulted in a material with promoted antibacterial efficacy against S. aureus for up to 5 days of in vitro culture when compared to nonanodized alloy.