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Journal of Nanomaterials
Volume 2015 (2015), Article ID 832762, 10 pages
http://dx.doi.org/10.1155/2015/832762
Research Article

Antibacterial Activity and Cytocompatibility of PLGA/CuO Hybrid Nanofiber Scaffolds Prepared by Electrospinning

1Department of Polymer Science and Engineering, School of Applied Chemical Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea
2Polymer Research Laboratory, Department of Chemistry, IIT, Roorkee 247667, India

Received 8 December 2014; Revised 21 February 2015; Accepted 5 March 2015

Academic Editor: Tamer Uyar

Copyright © 2015 Adnan Haider et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The PLGA/CuO hybrid nanofibers scaffolds were prepared via electrospinning technique. The presence of CuO in the PLGA scaffolds was confirmed by transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). The scaffolds were subjected to various antibacterial and cytobiocompatibility tests. The results not only showed excellent adhesion, proliferation, and viability (live/dead staining) for fibroblastic cells but also revealed that PLGA/CuO hybrid nanofiber scaffolds inhibited both Gram-positive and Gram-negative bacterial growth. The mechanism of the antibacterial activity was concluded to be based on the CuO nanoparticles and Cu++ ions release. It is, therefore, evaluated that PLGA/CuO hybrid nanofiber scaffolds can be a useful candidate for wound dressing.