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Journal of Nanomaterials
Volume 2015, Article ID 836761, 8 pages
Research Article

Magnetization Reversal and Specific Loss Power of Magnetic Nanoparticles in Cellular Environment Evaluated by AC Hysteresis Measurement

Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan

Received 30 January 2015; Accepted 5 May 2015

Academic Editor: Yong Zhu

Copyright © 2015 Satoshi Ota et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effect of intracellular hyperthermia induced by magnetic nanoparticles (MNPs) has been evaluated using a theoretical model. In this study, magnetization reversal of MNPs in the cellular environment under an AC magnetic field was evaluated on the basis of measured AC hysteresis loops. The specific and intrinsic loss powers—SLP and ILP—were also estimated from the area of AC hysteresis loops. The measured samples were a liquid sample dispersed in water, a fixed sample mixed with an epoxy bond, and a cellular sample. In the cellular environment, the rotations of particles and magnetic moments were inhibited by particle-cell and dipole-dipole interactions, respectively. The heat dissipation of the MNPs in the cellular environment was lower than that of the liquid and fixed samples. Moreover, the SLP in a single cell was estimated. The temperature increase of a single cell was calculated on the basis of the conventional theoretical model and the SLP measured in a single cell.