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Journal of Nanomaterials
Volume 2015, Article ID 970542, 8 pages
http://dx.doi.org/10.1155/2015/970542
Research Article

Fabrication and Evaluation of Polycaprolactone/Gelatin-Based Electrospun Nanofibers with Antibacterial Properties

1Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Johor, Malaysia
2Advanced Membrane Technology Research Centre, Universiti Teknologi Malaysia, 81310 Johor, Malaysia

Received 8 September 2014; Accepted 27 November 2014

Academic Editor: Qi Wang

Copyright © 2015 Lor Huai Chong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanofibrous scaffolds were fabricated through blending of a synthetic polymer, polycaprolactone (PCL), and a natural polymer, gelatin (GE), using an electrospinning technique. Processing and solution parameters were optimized to determine the suitable properties of PCL/GE-based nanofibers. Several characterizations were conducted to determine surface morphology by scanning electron microscopy (SEM), wettability using water contact angle measurement, and chemical bonding analysis using attenuated total reflectance (ATR) of PCL/GE-based nanofibers. Experimental results showed that 14% (w/v) PCL/GE with a flow rate of 0.5 mL/h and 18 kV demonstrated suitable properties. This nanofiber was then further investigated for its in vitro degradation, drug loading (using a model drug, tetracycline hydrochloride), and antibacterial testing (using zone inhibition method).