Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery

Figure 2

Pseudoternary phase diagram with surfactant mixture of Tween 80 : Carbitol. Pseudoternary phase diagram for a mixture of (a) IPM, water, and surfactant mixture at (a1) 60 : 40 (HLB = 10.7), (a2) 65 : 35 (HLB = 11.2), and (a3) 70 : 30 (HLB = 11.8) weight ratio of Tween 80 : Carbitol and (b) ethyl oleate, water, and surfactant mixture at (b1) 90 : 10 (HLB = 13.9), (b2) 95 : 5 (HLB = 14.5), and (b3) 100 : 0 (HLB = 15) weight ratio of Tween 80 : Carbitol. Filled circles (●) represent studied points, and black areas represent the self-emulsifying regions.

(a)

(b)