Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery

Table 1

Solubility of Ptx in various oils, surfactants, and cosolvents.

	Solubility^# (mg/mL)
Oils
Olive oil	1.00 ± 0.14
Soybean oil	2.29 ± 0.01
IPM (isopropyl myristate)	2.46 ± 0.03
Ethyl oleate	2.88 ± 0.08
Oleic acid	0.38 ± 0.07
Surfactants
Carbitol	70.09 ± 1.02
Cremophor® EL	20.13 ± 0.42
Tween 80	52.64 ± 0.77
Cremophor RH40	30.52 ± 1.67
Solutol HS 15	20.74 ± 1.81
Cosolvents
PEG 400	43.28 ± 0.08
Ethylene glycol	9.62 ± 0.25
Propylene glycol	14.35 ± 0.13
Ethanol	32.27 ± 0.29

From Sun et al. [34]
^#Mean ± SD ( = 5).