Preparation and Evaluation of Solid-Self-Emulsifying Drug Delivery System Containing Paclitaxel for Lymphatic Delivery

Table 2

The results of droplet size measurement in surfactant combination tests^#.

Oil	Ratio (%)		HLB	Droplet size (nm)
	Tween 80 (HLB = 15)	Carbitol (HLB = 4.2)		Mean	SD
Soybean oil; (required HLB, 6~7)	15	85	5.8	316	33.9
	20	80	6.4	277	2.49
	25	75	6.9	473	182
Ethyl oleate; (required HLB, 14~15)	90	10	13.9	10.5	0.596
	95	5	14.5	11.1	0.205
	100	0	15	11.5	0.807
IPM; (required HLB, 10~12)	60	40	10.7	12.9	0.170
	65	35	11.2	13.1	0.125
	70	30	11.8	13.2	0.974

The weight ratio of oil : surfactant mixture was fixed at 1 : 9. SD is standard deviation ( = 5).