Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies

Figure 1

Schematic illustration for formation of polymer nanoparticle, in situ administration, slow and sustained release in vivo, accumulation in tumor tissue, and controlled intracellular drug release of polymer nanoformulation. Upon entering the tumor cells, the nanoparticle releases the therapeutic agents when subjected to stimuli, such as light activation, enzyme, and lower pH (pH < 6.8), thereby inducing cell death.