|
| Nanoparticle type | Target | Size | Toxicity evaluation | Nanocompound |
|
| Metal nanoparticles | integrins | 107.8 ± 11.4 nm | Not evaluated | cRGD-iron oxide nanochains (RGD-NC) [48] |
| | HER2 | 25 nm | In vitro cytotoxicity study | Herceptin-MnO nanoparticles [49] |
| | 185 nm | Not evaluated | Anti-HER2 antibody-conjugated silica-coated magnetic-fluorescent gold nanoshells [50] |
| | LH/CG or LHRH receptors | 10 nm | Not evaluated | CG- or LHRH-superparamagnetic iron oxide nanoparticles (SPIONs) [51, 52] |
| | C-C chemokine receptor 5 | 21.5 ± 1.9 nm | In vitro cytotoxicity study | d-Ala1-peptide T-amide (DAPTA)-conjugated PdCu@Au tripods radiolabeled with 64Cu [53] |
| | uPA receptor | 18 nm | Not evaluated | uPA ATF-magnetic iron oxide (ATF-IO) nanoparticles [54] |
| | CD44 or folic receptors | 12.8 nm (diameter) × 91.7 nm (length) for GNTs; 30 nm for MNPs | In vitro cytotoxicity study | Anti-CD44- or folate-conjugated golden carbon nanotubes (GNTs) and spherical magnetic nanoparticles (MNPs) [55] |
|
| Silicon nanoparticles | CD105 | 175.3 ± 9.7 nm | Not evaluated | TRC105(Fab)-conjugated 64Cu-fluorescent labeled mesoporous silica nanoparticles (MSNs) [56] |
|
| Composite nanoparticles | — | 8.5 ± 0.8 nm (polydispersity index = 0.31 ± 0.11) | Not evaluated | 89Zr-labeled high-density lipoprotein nanoparticles (89Zr-rHDL) [57] |
| | — | 150 nm | Not evaluated | Positron-emitting magnetic nanoconstructs (PEMs): PLGA-phospholipid nanoparticles encapsulating ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) and 64Cu (DOTA) [58] |
| | — | 1,000 nm | Not evaluated | 64Cu-discoidal polymeric nanoconstructs (DPNs) composed of PLGA chains, multiarm PEG acrylate chains, lipid-DOTA chains, lipid-Rhodamine B dye, and USPIOs [58] |
| | Transferrin receptors | 112 to 165 nm | Not evaluated | Transferrin-PEG-decorated polyglycerol magnetic nanogels (MNGs) [59] |
| | HER2 | 40 ± 1 nm (polydispersity index = 0.15 ± 0.06) | In vitro cytotoxicity study | Thiolated neu antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs) coated with copolymer of chitosan and PEG (NP-neu) [60] |
| | 67 ± 5 nm | In vitro cytotoxicity study | Herceptin-dextran-coated magnetic iron oxide nanoparticles (SPIOs) [61] |
|
