Characterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy

Figure 4

(Images of (a), (b), and (c) in Figure 4 are parts of figures from reference.) The mechanical signatures of α-Syn conformational classes recorded by SMFS [64]. (a) Schematic representation of the polyprotein constructs used in the work. (b) Example of curve characterized by a featureless region assigned to the stretching of α-Syn moiety having, in this case, the mechanical properties of a random coil. (c) Example of the curves featuring the β-like signature of α-Syn, showing seven practically indistinguishable unfolding events of similar magnitude and spacing.

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