Advances on the Use of Biodegradable Proteins/Peptides in Photothermal Theranostics

Table 1

A summary of the various kinds of protein-based photothermal theranostics.

Proteins		PTCAs	Laser irradiation	Model	Other functions	Ref.
Serum albumins	HSA	ICG	808 nm, 0.4 W/cm^2, 10 min	4T1 tumor-bearing mice	FL imaging; chemotherapy	[38]
		ICG	808 nm, 0.8 W/cm^2, 5 min	4T1 tumor-bearing mice	FL and PA imaging; PDT	[37]
		IR825	808 nm, 0.8 W/cm^2, 5 min	4T1 tumor-bearing mice	FL and MR imaging	[39, 40]
		IR780	808 nm, 1 W/cm^2, 5 min	CT26 tumor-bearing mice	FL imaging; PDT	[41]
		CySCOOH	808 nm, 1 W/cm^2, 5 min	4T1 tumor-bearing mice	FL and PA imaging	[42]
		Gold nanoshell, ICG	808 nm, 2 W/cm^2, 15 min	HeLa and MDA-MB-231 cells	FL imaging; PDT; chemotherapy	[43]
		Gold nanorod	808 nm, 2 W/cm^2, 15 min	4T1 cells	Chemotherapy	[44]
	BSA	Cypate	785 nm, 1.5 W/cm^2, 3 min	4T1 tumor-bearing mice	FL, MR, and PA imaging	[46]
		CuS	808 nm, 0.7 W/cm^2, 15 min	HeLa tumor-bearing mice	N/A	[47]
		rGO	808 nm, 0.6 W/cm^2, 5 min	MCF-7 tumor-bearing mice	PA imaging	[48]
		IR825	808 nm, 0.5 W/cm^2, 5 min	4T1 tumor-bearing mice	FL and MR imaging; PDT	[28]
		Squaraine	680 nm, 20 W/cm^2, 30 min	KB tumor-bearing mice	FL imaging	[49]
		Polypyrrole	808 nm, 0.5 W/cm^2, 5 min	4T1 tumor-bearing mice	FL and MR imaging; PDT	[50]
	Other proteins	Ferritin	IR-820	808 nm, 0.5 W/cm^2, 10 min	4T1 tumor-bearing mice	FL and PA imaging	[51]
CuS			808 nm, 0.8 W/cm^2, 5 min	U87MG tumor-bearing mice	PET and PA imaging	[52]
HBV core protein		Gold dot	655 nm, 24 W/cm^2, 20 min	MDA-MB-468 tumor-bearing mice	FL imaging	[53]
Gelatin		CuS	808 nm, 6 W/cm^2, 5 min	HeLa cells	PA imaging; chemotherapy	[54]
		Polyaniline or Cu9S5	808 nm, 0.5 W/cm^2	H22 tumor-bearing mice	PA imaging; chemotherapy	[55, 56]
Antibody		ICG	808 nm, 6 W/cm^2, 200 s	1483 cells	Cell targeting	[57]
		Gold nanorod	808 nm, 3 W/cm^2, 8 min	Hep-2 tumor-bearing mice	Cell targeting	[58]
Phycocyanin		Carbon nanotube	808 nm, 0.5 W/cm^2, 5 min	MCF-7 cells	PDT	[59]
Peptides		NapFFKYp	ICG	808 nm, 0.8 W/cm^2, 5 min	HeLa tumor-bearing mice	FL and PA imaging	[60]
		PAsp	ICG, cypate	785 nm, 1 W/cm^2, 5 min	A549 tumor-bearing mice	FL imaging	[61]
		PLL-PLLeu	ICG	808 nm, 1 W/cm^2, 5 min	H460 cells	FL imaging	[62]